解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60-110) of human pleiotrophin (hPTN), using 2-chlorotrityl chloride resin (CLTR-Cl) following the 9-fluorenylmethyloxycarbonyl/tert-butyl (Fmoc/tBu) methodology and with the standard N,N'-...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0753-6
更新日期:2011-05-01 00:00:00
abstract::Carnosine is found in high concentrations in skeletal muscles, where it is involved in several physiological functions. The muscle carnosine content measured within a population can vary by a factor 4. The aim of this study was to further characterize suggested determinants of the muscle carnosine content (diet, gende...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0749-2
更新日期:2011-04-01 00:00:00
abstract::Several descriptors of protein structure at the sequence and residue levels have been recently proposed. They are widely adopted in the analysis and prediction of structural and functional characteristics of proteins. Numerous in silico methods have been developed for sequence-based prediction of these descriptors. Ho...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0721-1
更新日期:2011-03-01 00:00:00
abstract::Subcellular localization is an important protein property, which is related to function, interactions and other features. As experimental determination of the localization can be tedious, especially for large numbers of proteins, a number of prediction tools have been developed. We developed the PROlocalizer service t...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0724-y
更新日期:2011-03-01 00:00:00
abstract::Astrocytes are glial cells in the central nervous system (CNS) that play key roles in brain physiology, controlling processes, such as neurogenesis, brain energy metabolism and synaptic transmission. Recently, immune functions have also been demonstrated in astrocytes, influencing neuronal survival in the course of ne...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0691-3
更新日期:2011-02-01 00:00:00
abstract::In this study, an optically active diamine, N,N'-(pyromellitoyl)-bis{N-[4(4-aminophenoxy)phenyl]-2-(4-methyl)pentanamide} (1) containing amino acid L-leucine was prepared in three steps. The step-growth polymerization of this chiral diamine with several diisocyanates in room temperature ionic liquid (IL), 1,3-dipropyl...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0660-x
更新日期:2011-02-01 00:00:00
abstract::In this study, we investigated the activating role of Mcm1p at ARG1 during arginine starvation. Our results showed that two Mcm1p binding sites positively contribute to ARG1 transcription and cell growth. Especially, we provide strong evidence that the Mcm1p binding sites play a positive role in ARG1 transcription to ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0687-z
更新日期:2011-02-01 00:00:00
abstract::The transient receptor potential channels TRPV2 and TRPV5 belong to the vanilloid TRP subfamily. TRPV2 is highly similar to TRPV1 and shares many common properties with it. TRPV5 (and also its homolog TRPV6) is a rather distinct member of the TRPV subfamily. It is distant for being strictly Ca(2+)-selective and featur...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0712-2
更新日期:2011-02-01 00:00:00
abstract::Zinc exhibits antidepressant-like activity in preclinical tests/models. Moreover, zinc homeostasis is implicated in the pathophysiology of affective disorders. The aim of the present study was to examine the effect of chronic zinc, citalopram and imipramine intraperitoneal administration on the presynaptic and extrace...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0641-0
更新日期:2011-01-01 00:00:00
abstract::Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activity of synthesised all-D: - and all-L: -cupiennin 1a towards pro- and e...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0471-0
更新日期:2011-01-01 00:00:00
abstract::Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0601-8
更新日期:2010-11-01 00:00:00
abstract::The N-terminal 1-34 fragment of parathyroid hormone (PTH) is fully active in vitro and in vivo and it can reproduce all biological responses characteristic of the native intact PTH. Recently, analogues of PTH(1-11) fragments with helicity-enhancing substitutions have been demonstrated to yield potent analogues of PTH(...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0591-6
更新日期:2010-11-01 00:00:00
abstract::N-acetylaspartate (NAA), an acetylated derivative of L-aspartate (Asp), and N-acetylaspartylglutamate (NAAG), a derivative of NAA and L-glutamate (Glu), are synthesized by neurons in brain. However, neurons cannot catabolize either of these substances, and so their metabolism requires the participation of two other ce...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-010-0656-6
更新日期:2010-11-01 00:00:00
abstract::In a previous study, we elucidated the apoptotic mechanism mediated via Fas/FasL-dependent pathway in mitomycin C-treated cervical carcinoma cells. In this study, 2-D and MALDI-TOF analyses were performed in order to search mitomycin C-induced modulators in cervical carcinoma cells. Some protein spots down- or up-regu...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0568-5
更新日期:2010-11-01 00:00:00
abstract::Amino acid and glucosinolate biosynthesis are two interdependent pathways; amino acid synthesis as a part of primary metabolism provides the precursors for glucosinolate biosynthesis in secondary metabolism. In our previous studies, the combination of coexpression analysis and metabolite profiling led to the identific...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0681-5
更新日期:2010-10-01 00:00:00
abstract::Methionine (Met) is an essential amino acid for all organisms. In plants, Met also functions as a precursor of plant hormones, polyamines, and defense metabolites. The regulatory mechanism of Met biosynthesis is highly complex and, despite its great importance, remains unclear. To investigate how accumulation of Met i...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0562-y
更新日期:2010-10-01 00:00:00
abstract::The human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (TAT) protein, a member of the protein transduction domain (PTD) superfamily, can deliver heterologous proteins across most biomembranes without losing bioactivity. However, there is no report on whether the TAT core domain containing the ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0534-2
更新日期:2010-08-01 00:00:00
abstract::Several new beta,beta-dihalo and beta-halo-beta-substituted dehydroalanines and dehydrodipeptides were synthesized by reacting the corresponding dehydroamino acid derivative with a N-halosuccinimide or in the case of beta,beta-di-iododehydroalanines with iodine. The results obtained confirmed that the stereochemical o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0466-x
更新日期:2010-07-01 00:00:00
abstract::We present an optimized procedure for the synthesis of (S)-vinylglycine from (S)-methionine. The key step is a solvent free pyrolysis of an intermediate sulfoxide at high temperature. Using our optimized reaction conditions, Cbz-protected vinylglycine was obtained in high yield and with almost no side products. The pr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0460-3
更新日期:2010-07-01 00:00:00
abstract::Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0464-z
更新日期:2010-07-01 00:00:00
abstract::Protein and peptide oxidation is a key feature in the progression of a variety of disease states and in the poor performance of protein-based products. The present work demonstrates a mass spectrometry-based approach to profiling degradation at the amino acid residue level. Synthetic peptides containing the photosensi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0440-7
更新日期:2010-06-01 00:00:00
abstract::Reports on nucleobase-containing chiral peptides (both natural and artificial) and achiral pseudopeptides are reviewed. Their synthesis, structural features, DNA and RNA-binding ability, as well as some other interesting applications which make them promising diagnostic/therapeutic agents of great importance in many a...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-010-0567-6
更新日期:2010-06-01 00:00:00
abstract::Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0432-7
更新日期:2010-06-01 00:00:00
abstract::We report the solid phase synthesis and some pharmacological properties of 24 oxytocin (OT) analogues. Basic modifications at position 9 (introduction of L- or D-beta-(2-thienyl)-alanine [L- or D-Thi], or L- or D-3-Pyridylalanine [L- or D-3-Pal]) were combined with D-tyrosine(OEthyl) [D-Tyr(Et)] or D-1-naphthylalanine...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0372-2
更新日期:2010-05-01 00:00:00
abstract::The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [(3)H]taurine release...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0351-7
更新日期:2010-05-01 00:00:00
abstract::Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium ph...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-009-0359-z
更新日期:2010-05-01 00:00:00
abstract::The hepatitis B core (HBc) protein has been used successfully in numerous experiments as a carrier for heterologous peptides. Folding and capsid formation of the chimeric proteins is not always achieved easily. In silico analyses were performed to provide further comprehension of the feasibility for predicting success...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0365-1
更新日期:2010-05-01 00:00:00
abstract::D-Aspartic acid (D-Asp) is an endogenous amino acid present in neuroendocrine systems. Here, we report evidence that D-Asp in the rat is involved in learning and memory processes. Oral administration of sodium D-aspartate (40 mM) for 12-16 days improved the rats' cognitive capability to find a hidden platform in the M...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0369-x
更新日期:2010-05-01 00:00:00
abstract::In the present study, we report the synthesis and biological evaluation of a series of new non-peptide PAR(1) mimetic receptor antagonists, based on conformational analysis of the S(42)FLLR(46) tethered ligand (TL) sequence of PAR(1). These compounds incorporate the key pharmacophore groups in the TL sequence, guanidy...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0306-z
更新日期:2010-04-01 00:00:00
abstract::Granulocyte-colony stimulating factor stimulates production and antibacterial function of neutrophiles. Therapy using the recombinant protein drug represents a major step forward in oncology. The protein has not been, however, completely sequenced at the protein level and this formed the rationale of the current study...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0312-1
更新日期:2010-04-01 00:00:00
abstract::This study tested the hypothesis that L-arginine (Arg) may stimulate cell proliferation and prevent lipopolysaccharide (LPS)-induced death of intestinal cells. Intestinal porcine epithelial cells (IPEC-1) were cultured for 4 days in Arg-free Dulbecco's modified Eagle's-F12 Ham medium (DMEM-F12) containing 10, 100 or 3...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0334-8
更新日期:2010-04-01 00:00:00
abstract::This study investigated the effect of different sampling environments on hemolymph amino acid content of individual Drosophila melanogaster larvae. Hemolymph was collected from individual third instar larvae under cold-anesthetized, awake, and stress conditions. Qualitative and quantitative hemolymph amino acid analys...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0284-1
更新日期:2010-03-01 00:00:00
abstract::Identifying protein-protein interactions (PPIs) is critical for understanding the cellular function of the proteins and the machinery of a proteome. Data of PPIs derived from high-throughput technologies are often incomplete and noisy. Therefore, it is important to develop computational methods and high-quality intera...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0295-y
更新日期:2010-03-01 00:00:00
abstract::N-Acetyl-AA(amino acid)-NHtBu derivatives of all 20 naturally occurring amino acids have been synthesized. Syntheses were performed via solution-phase methodology with yields that allow for access to gram quantities of substrates, in most cases. Syntheses include the coupling of a hindered amine, tert-butylamine, with...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0279-y
更新日期:2010-03-01 00:00:00
abstract::Immobilization of papain on Sepharose 6B in the presence of different concentrations of cysteine affected the enzyme activity depending on cysteine concentration. The maximum specific activity was observed when papain was immobilized with 200 mM cysteine. The immobilization process brought significant enhancement of s...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0302-3
更新日期:2010-03-01 00:00:00
abstract::We have been studying control mechanisms of gene expression in early embryogenesis in a South African clawed toad Xenopus laevis, especially during the period of midblastula transition (MBT), or the transition from the phase of active cell division (cleavage stage) to the phase of extensive morphogenesis (post-blastul...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-009-0403-z
更新日期:2010-02-01 00:00:00
abstract::Polyamines are small organic polycations essential for cell proliferation and survival. Antizymes (AZs) are small proteins regulated by polyamines that inhibit polyamine biosynthesis and uptake in mammalian cells. In addition, antizyme functions are also regulated by antizyme inhibitors, homologue proteins of ornithin...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-009-0419-4
更新日期:2010-02-01 00:00:00
abstract::The unusual basic amino acid, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is a product of a unique posttranslational modification that occurs in only one cellular protein, euk...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-009-0408-7
更新日期:2010-02-01 00:00:00
abstract::This mini review deals with the modern aspects of the spectroscopy and structural elucidation of amino acid derivatives and small biologically active compounds. Free peptide bond rotation in these systems yields various conformers, which possess differing biological activities. Another phenomenon is the intermolecular...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-008-0220-9
更新日期:2010-01-01 00:00:00
abstract::An aromatic chiral diacid monomer, 5-[4-(2-phthalimidiylpropanoylamino)-benzoylamino]isophthalic acid was synthesized in five steps under conventional heating in high yield and purity. A series of soluble, thermally stable and optically active polyamides (PA)s containing pendent groups made of phthalimide, flexible L:...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0186-7
更新日期:2009-10-01 00:00:00